Fertility Research Studies at WCFC

1. Human Oocyte Cryopreservation, A Frozen Oocyte Birth Following Failed Fresh IVF in the Same Patient – A Case Report
   Description of a a successful live birth using frozen oocytes instead of frozen
   embryos after an initial unsuccessful IVF cycle.
2. Human Oocyte Cryopreservation, Preliminary Results of Survival, Fertilization and Cleavage Rate of Frozen Oocyte Using a New Modified Slow – Freeze Protocol
   Description of the survival rate, fertilization rate, and
   cleavage rate of a new slow-freeze technique for human oocytes.
3. A Frozen Egg Birth, a Frozen Embryo Birth, and a Fresh Embryo Twin Birth: Multiple Outcomes From a Single IVF Cycle
   A 30-year-old woman with polycystic ovarian syndrome (PCOS) underwent controlled ovarian hyperstimulation (COH) for in vitro fertilization. A limited number of oocytes were inseminated with Intracytoplasmic Sperm Injection (ICSI). Surplus oocytes were
   cryopreserved by a slow freeze method. In November of 2001, the patient delivered healthy twins and decided to donate all unused cryopreserved oocytes and embryos. Donated oocytes were given to 42 year old matched primary infertility recipient.
   
4. Effects of Transfer Location on IVF Outcomes  
   The impact of transfer distance from the fundus (TDF) on clinical pregnancy rate (PR) and ectopic pregnancy rate in 699 ultrasound-guided embryo transfers.
5. A New Methodology to Evaluate Beta 3 Integrin as a Marker for Uterine Receptivity 
   The presence of the beta3 integrin molecule in the endometrium mayplay an important role for embryo implantation. This study evaluates a new method using beta3 integrin as a marker for uterine receptivity in women with two unsuccessful in vitro fertilization (IVF) cycles.
6. Parallel Comparison Study of Estradiol and FSH Between Elecsys and Access2® Analyzers in Relationship to Number of Oocytes and Pregnancy Outcome  
   serum FSH and estradiol levels are compared using both the Roche Elecsys 2010 and the Beckman-Coulter Access 2 analyzers. This parallel study was performed during the implementation of a new laboratory methodology at our Orange County fertility center.
7. 48 Months Retrospective Study on Pregnancy Rates
   A 48 months study was performed on 750 sequential patients undergoing Assisted Reproductive Technology at West Coast Fertility Centers between 1999-2002.
8. New Fertility Development - Beta 3 Integrin 
   Integrins have a major role in endometrial receptivity. Abnormal endometrial integrin beta 3 expression might be a major cause of unexplained infertility and also recurrent pregnancy loss.
9. A Non-Incisional Doppler Guided Transvaginal Approach for Uterine Artery Identification May Lead to a Less Invasive Means to Control Uterine Perfusion 
   Determination of the location and depth of the uterine arteries from the vaginal fornix using a Doppler guided non-incisional transvaginal approach.
10. Determination of InterLeukin-8 In Amniotic Fluid  
    Determination of interleukin-8 in amniotic fluid is suitable to avoid a fetal inflammatory response syndrome.